Evaluation of the degree to which the impact of stage of Parkinson's disease on
  
   Lead Investigator:    Kathryn Harris
   Institution      :    Roosevelt University
   E-Mail           :    kharris24@mail.roosevelt.edu
   Proposal ID      :    537



   Proposal Description:
   The goal of the project is to examine the relationship between severity of    motor symptoms, depressive symptoms, and cognitive deficits within a              Parkinson's disease population. Given the prominence of nonmotor symptoms of      Parkinson's disease coupled with a dearth of current effective treatments         targeting many of these symptoms, it is important to continue to bolster the      understanding of the ways in which nonmotor symptoms (e.g., cognitive deficits    and depression) relate to motor symptoms in Parkinson's disease. These   would be used to support the development of integrative treatment interventions   targeting nonmotor symptoms of Parkinson???s disease, particularly depressive     symptoms and cognitive difficulties. The specific objective is to test the        hypothesis that depressive symptomatology mediates the relationship between       severity of motoric symptoms of Parkinson's disease and cognitive deficits.       Support for this hypothesis would highlight the significance and functional       impact of depressive symptomatology in patients with Parkinson's disease.